I haven't used the central management of McAfee's corporate offering, but I can say the end point stuff is horrible. We are constantly manually cleaning viruses, and in some instances re-imaging PC's here at my office. I don't think I've ever seen it actually catch something. We were running Symantec's offering a few years ago, and complaining about it but would now gladly go back to it over McAfee. I have played a bit with both ends of Trend Micro's corporate offering and liked it a lot. The endpoints seemed low impact, but did a good job protecting and cleaning viruses.

I also have been recommending MSE to friends & family for home use.