Joking aside, unless the Neo had worse-than-soundblaster-16 audio quality, you'd probably be fine with it in a car. Let's face it, a car is such a bad environment sonically:

It's shape is determined by passenger comfort and aerodynamics.
Speaker placement is determined by "Where will they fit?".
The interior surfaces have a mixture of bright and dead tonal qualities that are determined without regard to audio - the windows and seats need to be in a particular place in a car.
The entire structure of a car needs to be light, hence maximising the odds of components resonating.
There's somewhere between about 4000 and 84000 explosions a minute occuring about a yard in front of you.
There's only about a foot and 3mm of glass between you and gale-force wind.
And, of course, let's not forget road noise from the tires.

All told, I'm very impressed that car systems sound as good as they do..