I agree, Girder has worked very well for me for 4 years now. It's true that it's a bit annoying to set up, but once you have the basic functions down, it's quite easy to add new commands.

And Bruno, no offense, but ATI's remote control software is nothing but user interface. There is absolutely no power in it. Hell, if I want to control anything but ATI's own software I have to go through a much more confusing process than anything Girder can throw at me. The only thing that ATI's software has going for it is better control over the mouse. But the mouse isn't necessary in myHTPC, so now I'm fine with that (I've got it working pretty well anyway).