Do you think it'd be worth it to run a raid 0 config with serial ATA?

Yes, definitely !
Your HD speed (and thus your overall system speed since the HD is still the slowest part in a PC) will increase immensely. The pure HD speed will double.

Only bad thing is that this also doubles the risk of loosing all your data, because if one of those HD's fails, all your data is gone. But not to worry, if you backup early and backup often there's nothing to worry about.