If you can get mp3s out of it (which I didn't think they did) then, yeah. You should be able to use those with the Karma.

It might be arbitrarily difficult, though. They might force you to burn a CD in order to get the mp3s, and then you'd have to copy 'em back off. Or they might not. But if they claim that iTunes can provide you with mp3s that can be used in an mp3 CD player, then you can use those same mp3s with the Karma.