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What size is your music collection? At 18,254 mine is working fine...

It's about the same order of magnitude (around 24K songs). What kills it is if you ask it to play the whole collection shuffled. It takes almost two minutes before it starts actually playing anything, and the UI is completely unresponsive while it's thinking about it.

(This is with SlimServer running directly on my Infrant file server, with some kind of embedded Sparc processor, but I saw similar behavior on my older dual-1GHz G4 PowerMac.)