FYI, I'm using that exact same card in a mid size tower. It has been an awesome video card. You want to play Prey at 1920 X 1200 with all graphics settings at max? No problem! This thing flys! Now as for size, it IS a monster and runs hot even in this big case. I have just enough room to plug the power connector into it. Fitting that thing into a shuttle might be pretty tricky.