I don't think the shield thing is really a complete answer in that the "body" must be exposed when changing the lenses mainly due to protrusion of the lens into the body. Once dust is in the body, it is disturbed by the mirror action, etc and the charges applied to the sensor attract the dust. High humidity can actually "weld" it to the sensor. There is in essence a shield (although incomplete) currently in place in the form of the mirror. If people are considering buying a digital SLR with interchangable lenses, do not ignore this as it can be enormously frustrating. if you get even minute dust "threads" or fibers on the sensor, it can require extensive work in Photoshop. One can minimize the effect by shooting with as large an aperture as possible which will not bring the dust into focus. I have cleaned sensors before and it is nerve-wracking (or is it nerve-racking). Actually with a Nikon, there is a clear protective shield on the top of the sensor but it still attracts dust. I take every precaution I can to keep it from happening short of never changing lenses (which would kind of defeat the purpose of the camera design).
I not trying to ignore that current "real" SLRs are better than SLR-lites at all. In fact, that is exactly why people pay more for them. However, if you accept an extension (and I don't think it is that big a step) of Moore's law since it largely involves the minaturization of electronics, tomorrow's SLR-lite (selfcontained) will be where today's real SLR (with interchangable lenses) is which will be moore (spelling pun intended) than acceptable for DWallach to shoot a picture of his daughter at night under stadium lights without renting or buying a $7000 lens.
I think the technology is there today if it was repackaged. Now taking Hybrid8's point of Nikon's margins and how such a camera would cut their own profit. He is correct that Nikon has no motivation. There is, however, no such restriction on say FujiFilm, which manufactures SLR bodies only (in the pro class) that use Nikon lenses, from duplicating in a selfcontained package what 98% of pros shoot in a interchangable lens system. Now if you are a professional photographer or advanced amateur, would you rather lug around 30 lbs of gear or 5 lbs?
All that being said, I got to thinking about noise levels at high ISOs. Try pushing ASA800 film to 1600 for low light applications and look at the "noise".
Here is link about preceived noise levels in actual practice.