Something like this would be useful for databases. Currently, as incredibly useful as they are, databases are still constrained in what they can do by the hard drive access times. The lower the access time, the more powerful a database you can design.
Most of us don't have the need for an application like this, nor do we have the money to throw at it. I'm going to do the next best thing, personally, and design a system around a ramdisk at some time in the near future. However, copying 2 gB of data from the hard drive every time you boot up is going to be a pain, and, if the system crashes, all that data is gone unless you copied the changes back to the hard drive. For my purposes, it should work out, but for people that cannot deal with these limitations, one of these solid state hdd's might be perfect.
-Biscuits