Yeah, I've got some moleskin in the medicine cabinet. Use it on my feet when I get blisters there. Wouldn't be useful on the fingertips, as I need to feel everything under them when I play. Playing guitar with moleskin on my fingers would be like trying to drive with boxing gloves and oversized clown shoes... do-able, but don't expect anything good to come of it.

Same goes for anything else that puts layers of anything between my skin and the strings. Anyone who plays guitar will know what I'm talking about, I'd think.

Although I have to say that looking for that second skin product might be worth a try. I could at least try it and see.