I'm not near as big as joe187, but at 6'4", 240, I have problems with a lot of cars too. Additionally, a lot of big men have problems with their knees, especially if they have played sports. The problem I have with most of the sedan types is that even when there is enough room, getting down into them and back out is bad on my bum knee (injured playing intramural soccer in college.) I can see that as a good reason to not get a LeSabre or something like that.
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~ John