Absolutely. I dislike WMV and QT files. Frankly, I'd be fine with Quicktime for the PC, but they insist on making stick its fingers in too many places of the OS by default, and then there's the fact that you simply cannot do full screen video, which makes absolutely no sense to me. Oh well, I really don't care these days because mplayer plays everything, full screen, and without any hooks into the OS whatsoever.
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Matt