I second the mousing surface notion. Optical mice hate surfaces with depressions or other imperfections. I've had 100% error rate with optical mice on those semi-hard plastic mouse pads because of this. Try a new mouse pad or a retro ball mouse.
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FireFox31
110gig MKIIa (30+80), Eutronix lights, 32 meg stacked RAM, Filener orange gel lens, Greenlights Lit Buttons green set