The best bet is to use a program that's intended for laying up multiple photos on a page and includes templates for just that. It's a lot easier than even using a general-purpose page layout application.

This is built into photo programs like Lightroom, but there should also be a decent selection of stand-alone products, perhaps even some free ones.

As far as printing goes however, the printer is going to get the N-up data, not just a single photo, AFAIK.