Well, it's good to remember that political and physical geographic borders frequently fail to coincide.
Oh, certainly. But some of those regions don't seem to correlate with either.
To use a recent example, I think that Milwaukee is definitely part of the midwest, but the plains and highland areas of Wisconsin probably are not.
Exactly. Attempting to define "regions" based on proximity of state boundaries to particular geological features is foolish. Regions are murky because they depend on history and culture as much as they do geography. Sometimes, if you're lucky, those coincide with state borders.