I have an asus rampage3, and the vertex 3 is connected to the on board sata 3 controller. So far, i confirm no issues at all. Upgrade from intel x25-m was done through the old and usual temporary mirroring method, so i had a mirror running for few minutes made up of one disc on the sata 2 controller and the other on the sata 3 one, and that worked just fine as well. So far this vertex 3 seems as good as it can be. :-)