I have a similar problem:

OS: Windows XP Pro
Version: Emplode v2.00-beta11

When attempting to connect to my Empeg via USB, using Windows XP Pro and Emplode, I recieved "Failed to open database connection (error 0x80040015)" at the "Connecting to player" task part of Synchronising. C:\Windows\System32\Drivers\RIOHD.sys version is 2.0-beta3 dated Jan. 3, 2001. When connecting the USB cable, the driver did install and give a "driver not test on XP / driver not signed" error, which I told XP to ignore.