Spell-check everything. If a hiring manager is having a bad day and has a stack of resumes, an obvious typo can earn you the trash bin.
This is SO important. I've just finished a hiring cycle here, and I can't tell you the number of resumes that got trashed immediately because of typos and poor seplling
In my hands, I look at it in one manner alone. I'm hiring someone to do a job that is going to require quality. The only way I know you is through your resume. If you have obvious errors on your resume, how can I assume that I'm not always going to be checking your work for you? No Thanks.
It's Max 2 pages. Get 5 other people to read it. Be VERY harsh on yourself about it, because if it's not perfect, then you aren't sending the best impression you can of yourself.
Now, the interview itself is yet another story....