Yeah, when we got hit with Nimda at work, we had TONS of those Outlook files on our machines. With funny names too like "backpack" etc. Eventually, the machines got very very slow and the hard drives filled up...

One cool thing about AntiVirus (at least Norton) is that you can scan networked drives. So, my laptop had Norton on it and I just tapped into all the infected machines via a crossover cable and started cleaning them up. It wont check the memory and registry, but it at least got these things on their feet enough to install their own AntiVirus SW.