Probably a silly idea, but what about a trackball?
http://www.logitech.com/en-us/mice-pointers/trackballs/wireless-trackball-m570

Ten years ago I used to have it (an older version) in my main PC and I loved it. I don't know why at some point I reverted to mouse, but every now and then I think I'd rather go back to it.

Of course, many hate trackballs, so it may just be me.
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