Looks like Andy and Bruno have covered most of what I'd also suggest. Here are a few others though:

I personally use Flipboard to access my Google Reader feeds.

Comixology if comics interest you at all
Reading Rainbow recently launched, the kids may enjoy that one
Jump is the Windows RDP client I use
iSSH for SSH and XWindows
Verbs for IM
Dark Sky for rain weather (may be US only)
Star Walk for star identification