How much do you want to spend on this? (other than as little as possible)
Could an option be to put your computer into a separate ducted and ventilated box, away from your desk. You could then run your CD drives in a separate box on your desk connected via firewire or USB2.
If you do this, a largish box with a slow moving, large diameter fan would be necessary; as would good quality monitor, keyboard and mouse cables.

OR

if you manage to get a new fan for your noisy display card, they are generally quieter than the factory installed cheapies.
Modifying your case to minimise turbulence and rubber mounting case fans helps too.