I run LMS on a Windows system only because it's already running SageTV 24/7, otherwise I'd be running it on my ReadyNAS, which is also on 24/7 and already holds all the music.

The Windows system boots from SSD and LMS' database and all cache files are stores on the same SSD. The web interface is usable but far from fast.

I think above all else, the main thing to note with regards to LMS is that it's finicky and has always had its share of issues/bugs. Currently I'm in the process of completely wiping it out and re-installing in hopes of getting back my track artwork, which suddenly disappeared for the majority of my collection the other day. At around the same time I updated to the latest 7.7.2 version I believe.