Another no for Remedy, I hated using it. If I was looking for issue tracking I would give FogBugz a go.

I have played with their trial and I like the simply approach they take, though I worry that it might become restrictive after a while.

http://www.fogcreek.com/FogBugz/index.html

My favorite bug tracking system isn't a bug tracking system at all. It is part of the CRM system from Onyx Software http://www.onyx.com/ . I work for Onyx Software on and off, they eat their own dog food so the bug tracking side of their software works the way the development team want it to. It is very odd though when you are using the software with the bug to report the bug (and I did once have the problem of not being able to report a bug, because of the bug itself). There are benefits of having bug tracking as part of you CRM system, as bugs and feature requests can be fed straight into the system by the customers or the customer support team.