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I am 99.9% sure the wired controllers for the retail XBox 360 are standard USB. There is a small panel on the front of the 360 with standard USB ports. Chances are you can plug in a mouse and keyboard and have it work. I would be surprised if they didn't.... well not completely. The developers might have to make their game "keyboard aware."

The Xbox had standard USB controllers apart from an extra power line for the vibration motors and a proprietory plug. Didn't mean that it supported keyboard & mouse tho...