For what it's worth, the magic of HDMI-CEC plus an IR Blaster gadget have allowed my bog-standard TiVo remote, with its limited programmability, to drive my whole home theater for 95% of the daily use cases. Notably, hitting the TV power button causes the receiver to power up by itself, and hitting the TV power again causes the amp to power itself down again. The only other remote on the table is the Google TV remote, which you need for watching a Blu-ray or running apps. The original receiver remote has been collecting dust in the cabinet for years.

For somebody without a fancy receiver, most cable box remotes are kinda sorta universal ("for Sony, hold down this button then type this four digit number"), at least enough that they can do the job.

A Harmony, then occupies a vanishingly small slice of an already small market: people with lots of home theater gadgetry who don't want a forest of remote controls in front of them and haven't found a way around it with conventional universal remotes and/or HDMI-CEC.