It can be done. I know that Mark has tested out hijack using 128GB drives. There is a limit, based on LBA (that is from memory, please correct me if I am wrong), and a special kernel will need to be compiled to support larger drives. You would need to put an adapter on the laptop IDE cable, but you might be able to supply the power directly from the player.
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Paul Grzelak
200GB with 48MB RAM, Illuminated Buttons and Digital Outputs