I'm 30, and I haven't moderated that much. No drugs for me (I try to avoid OTC painkillers, too, but for the anti-inflamation benefit I was taking Naproxin Sodium recently while my foot healed). Alcohol, starting at 25, and fewer than a dozen times since.

I don't care what other people do, and I don't hold it over them, it's just not my thing. I agree about the bars, not my scene but sometimes I go along.