Absolutely. I'm sorry you don't like me reusing Harmony's terminology. Go back to that post and mentally replace "Activity" with "State-based macro".

If someone sold such a remote with a decent form factor for $250 or less, I'd be all over it. In fact, I posted a thread a while back requesting information about how to hack a Harmony 880, hoping I could get this exact feature set.

But no one does, and Harmony is the closest it gets.