Sure it would. It just has to default to "not connected" (MOSFETs turned off), and then they get turned on after the empeg determines what is actually hooked up.

Diodes could work too, without need for control, so long as the voltage drop isn't too much. The diodes on I2S inside the empeg would be oriented to only let current flow outward, and the diodes on the tuner's stub would be oriented to only let current flow in the direction the tuner expects. Very compatible.